Science
BlueGnome provides leading solutions for the investigation of copy number imbalance in the human genome. The main application areas include analysis of pre- and post-natal samples to identify genetic abnormalities related to developmental delay, investigation of cancer samples, and aneuploidy screening of single cells in IVF.
The study of an individual's genetic make-up or their genome has been of interest since DNA packaged into chromosomes was first discovered and found to be related to certian developmental disorders. More recently, since the first human genome was sequenced in the year 2000, a whole host of new technologies have allowed the analysis of the human genome in greater detail enabling a better understanding of the causes of genetic disorders and disease.
ArrayCGH is a technique that uses microarrays (glass slides spotted with DNA) to detect copy number imbalance in genetic samples with great sensitivity and resolution. BlueGnome’s technology platform comprises multiple innovations around the production, use, and analysis of microarrays for copy number analysis.
These pages explain the fundamental science behind arrayCGH and also a description of the main application areas. Also within these pages there are a number of scientific publications related to the investigation of copy number imbalance and links to online resources that can provide further information and are very powerful tools.
